Welcome to the Translational Genomics Lab
The UNC Lineberger Comprehensive Cancer Center Translational Genomics Lab (TGL) is a high-throughput core facility established in 2011 to provide comprehensive genomic services for investigators. Located in Marsico Hall on UNC’s School of Medicine campus, TGL’s mission is to support translational human cancer genomics research at UNC by providing a resource that balances rigor and flexibility to meet the needs of academic and clinical research that can ultimately produce optimized and validated processes for adoption in clinical labs.
Services
TGL performs sample processing and analyses for the molecular, pathologic, and genomic characterization of patient-derived specimens in preclinical research projects and clinical protocols. Our laboratory employs highly automated, as well as manual, platforms for reproducible high-throughput genomic assays. We have extensive experience generating usable data from highly degraded FFPE samples that would otherwise be rejected as unusable by larger sequencing facilities.
Offerings
- Nucleic acid extraction
- Nucleic acid quality control
- Genomic profiling
- Expression profiling
- Short-read sequencing
Milestones
- > 40 clinical trials supported
- > 20,000 nucleic acid extractions performed
- > 20,000 NGS libraries prepared
- > 17,000 NGS libraries sequenced
- > 13,000 NanoString assays performed
Financial Support
TGL services are subsidized by LCCC University Cancer Research Funds (UCRF).
Acknowledgement
We appreciate the opportunity to support your research. When publishing data generated through the Translational Genomics Lab, please include the core in your acknowledgement section and our Core Marketplace Research Resource Identifier (RRID) SCR_025231. This allows us to easily track the scientific impact of our services and will enable us to obtain financial and other support to continue to provide essential services. Currently, there are no specific grants that we ask you to cite in your manuscript. Please send a link of newly published work to lccctgl@unc.edu for us to include on this website. Thank you.